Born in Havana, Cuba, Miguel Angel Blanco trained at the National Ballet School of Cuba. Prior to joining the Joffrey, he performed as a principal dancer with the Ballet Nacional de Cuba, under the artistic direction of Alicia Alonso.

While dancing with the Ballet Nacional de Cuba, Blanco performed in Paris, London, Mexico, Venezuela, Dominican Republic, United States, Netherlands, Spain, Italy, China, and Egypt. Some principal roles with the company include Swan Lake (Prince Siegfried), Don Quixote (Basilio, Espada), Giselle (Albrecht), and Coppélia (Franz). Since joining the Joffrey, he has performed in a variety of works including lead roles in Lar Lubovitch's Othello (Othello), Frederick Ashton's Cinderella (Prince), Ronald Hynd's The Merry Widow (Danilo), Krzysztof Pastor's Romeo & Juliet (Romeo), Christopher Wheeldon's Swan Lake (Prince Sigfried), and Robert Joffrey's The Nutcracker (Cavalier). He has created leading roles in Stanton Welch's Son of Chamber Symphony and James Kudelka's Pretty BALLET.

Other significant performances include Le Corsaire Pas de Deux; Christopher Wheeldon's After the Rain, Continuum, and Liturgy; Jerome Robbins's In the Night (2nd Pas) and The Concert (or, The Perils of Everybody) (Husband); George Balanchine's Stravinsky Violin Concerto (Aria I); Jiří Kylián’s Forgotten Land (Black Pas); Yuri Possokhov's Bells and RAkU (Samurai); Edwaard Liang's Age of Innocence; Stanton Welch's Maninyas; Alexander Ekman's Tulle; Antony Tudor's Lilac Garden; and Nicolas Blanc's Evenfall.